Which substance is frequently self-medicated for relieving feelings of loneliness and depression?

People often self-medicate with various substances to manage emotional pain, such as loneliness and depression. Among the substances listed, alcohol is particularly common for this purpose. Alcohol can temporarily create feelings of euphoria and relaxation, which might make it appealing to individuals seeking to escape their feelings of sadness and isolation. This tendency to use alcohol as a means of coping with negative emotions is well-documented in both clinical and social contexts.

Cocaine, while it may initially increase mood and energy, does not typically serve as a long-term solution for feelings of loneliness or depression due to its stimulating properties and potential for significant negative effects, including addiction and withdrawal symptoms.

Marijuana is sometimes used for its calming effects but does not universally help in alleviating feelings of loneliness and depression as effectively as alcohol.

Heroin, being an opioid, can create a euphoric state but carries a high risk of addiction and severe negative consequences, which can overshadow any temporary feelings of relief.

Therefore, alcohol emerges as the most frequently self-medicated substance in relation to feelings of loneliness and depression due to its widespread availability and social acceptance as a coping mechanism.