Which drug is used to reverse opioid toxicity?

Naloxone, commonly known by its brand name Narcan, is specifically designed to reverse opioid toxicity. It is an opioid antagonist, which means it binds to the same receptors in the brain as opioids but without activating them. This action effectively displaces opioids from their receptor sites, reversing the effects of an overdose, such as respiratory depression and sedation. Naloxone works quickly, often restoring normal breathing within minutes when administered, making it a crucial medication in emergency situations involving opioid overdoses.

The other options listed serve different purposes. Disulfiram is used in the treatment of alcohol dependence but does not have any effect on opioids. Methadone is a long-acting opioid used for pain management and as part of drug dependence treatment but does not reverse opioid toxicity. Clonidine is primarily used to treat high blood pressure and can be used as part of opioid withdrawal management but does not directly reverse the effects of opioid overdose. Therefore, naloxone is the appropriate and effective choice for reversing opioid toxicity.