What is a major risk associated with poly-substance use?

The increased likelihood of overdose is a significant risk associated with poly-substance use because combining different substances can lead to unpredictable interactions. When individuals use multiple drugs simultaneously, the effects of one substance can amplify or alter the effects of another. This can cause respiratory depression, heightened toxicity, and an overall decrease in the body’s ability to manage and metabolize the substances, leading to a higher chance of overdose.

For example, mixing opioids with depressants like alcohol can severely impair respiratory function, creating dangerous and potentially fatal consequences. Furthermore, the individual may not be aware of the cumulative effects of the substances they are using, which can further heighten the risk. Understanding the compounds being mixed and their individual effects is crucial, as it ties directly into the risks of overdose associated with poly-substance use.